4.7 Article

Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition

期刊

NUTRIENTS
卷 14, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/nu14010098

关键词

dendropanoxide; hepatic fibrosis; hepatic stellate cells; autophagy; carbon tetrachloride

资金

  1. Kyungsung University

向作者/读者索取更多资源

In this study, the researchers found that dendropanoxide (DPX) extracted from Dendropanax morbifera has anti-fibrotic effects on hepatic fibrosis by inhibiting the activation of hepatic stellate cells (HSCs). DPX was able to suppress the expression of fibrotic markers and deposition of extracellular matrix in a mouse model of hepatic fibrosis induced by carbon tetrachloride. The researchers also demonstrated that DPX inhibits HSC activation by inhibiting autophagy.
Hepatic fibrosis results from chronic liver damage and is characterized by excessive accumulation of extracellular matrix (ECM). In this study, we showed that dendropanoxide (DPX), isolated from Dendropanax morbifera, had anti-fibrotic effects on hepatic fibrosis by inhibiting hepatic stellate cell (HSC) activation. DPX suppressed mRNA and protein expression of alpha-SMA, fibronectin, and collagen in activated HSCs. Moreover, DPX (40 mg/kg) treatment significantly lowered levels of liver injury markers (aspartate aminotransferase and alanine transaminase), expression of fibrotic markers, and deposition of ECM in a carbon tetrachloride-induced mouse model. Anti-fibrotic effects of DPX were comparable to those of silymarin in a hepatic fibrosis mouse model. As a possible mechanism of anti-fibrotic effects, we showed that DPX inhibited autophagosome formation (LC3B-II) and degradation of p62, which have important roles in HSC activation. These findings suggest that DPX inhibits HSC activation by inhibiting autophagy and can be utilized in hepatic fibrosis therapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据