期刊
NUTRIENTS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu14020353
关键词
polychlorinated biphenyls (PCBs); dioxins; telomere length (TL); cross-sectional study; Seguimiento Universidad de Navarra (SUN) study; nutritional epidemiology
资金
- Spanish Government-Instituto de Salud Carlos III
- European Regional Development Fund (FEDER) [RD 06/0045]
- European Regional Development Fund (FEDER) ( Fondo de Investigaciones sanitarias) [PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564, G03/140]
- PNSD [2020/021]
- University of Navarra
- Navarra Regional Government [27/2011, 45/2011, 122/2014]
This study aimed to evaluate the association of dietary exposure to polychlorinated biphenyls (PCBs) and dioxins with telomere length (TL). The results showed that dietary exposure to total PCBs and dioxin-like PCBs (DL-PCBs), as well as dioxins, was associated with shorter TL.
Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk of chronic disease. We hypothesized that dietary exposure to polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was to evaluate the association of dietary exposure to PCBs and dioxins with TL. In this cross-sectional study of 886 subjects older than 55 y (mean age: 67.7; standard deviation (SD): 6.1; 27% women) from the Seguimiento Universidad de Navarra (SUN) project. TL was determined by real-time quantitative polymerase chain reaction and dietary PCBs and dioxins exposure was collected using a validated 136-item Food Frequency Questionnaire. Multivariable linear regression models were used to control for potential confounding factors. Shorter TL was associated with dietary total PCBs (SD of T/S ratio/(ng/day) = -0.30 x 10(-7); 95% CI, -0.55 x 10(-7) to -0.06 x 10(-7)), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO TEQ (Toxic Equivalents)/day) = -6.17 x 10(-7); 95% CI, -11.30 x 10(-7) to -1.03 x 10(-7)), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = -5.02 x 10(-7); 95% CI, -9.44 x 10(-7) to -0.61 x 10(-7)), but not with dioxins (SD of T/S ratio/(pg WHO TEQ/day) = -13.90 x 10(-7); 95% CI, -37.70 x 10(-7) to 9.79 x 10(-7)). In this sample of middle-aged and older Spanish adults, dietary exposure to total PCBs and DL-PCBs alone and together with dioxins was associated with shorter TL. Further longitudinal studies, preferably with POPs measured in biological samples, are needed to confirm this finding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据