4.7 Article

Graptopetalum paraguayenseExtract Ameliorates Proteotoxicity in Aging and Age-Related Diseases in Model Systems

期刊

NUTRIENTS
卷 13, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/nu13124317

关键词

GP extract; neurodegenerative disease; Alzheimer's disease; amyloid-beta; autophagy; longevity

资金

  1. Minister of Science and Technology, Taiwan [MOST 106-2311-B-010-005, MOST 106-2320-B-077-001, MOST 110-2320-B-A49A-541]
  2. NIH Office of Research Infrastructure Programs [P40 OD010440]

向作者/读者索取更多资源

The GP extract has been shown to inhibit the growth of liver cancer cells, reduce pathological phenotypes of Alzheimer's disease, suppress beta-amyloid pathology, enhance AMPK activity, and improve autophagy in various cell lines and animal models, ultimately extending lifespan.
Declines in physiological functions are the predominant risk factors for age-related diseases, such as cancers and neurodegenerative diseases. Therefore, delaying the aging process is believed to be beneficial in preventing the onset of age-related diseases. Previous studies have demonstrated that Graptopetalum paraguayense (GP) extract inhibits liver cancer cell growth and reduces the pathological phenotypes of Alzheimer's disease (AD) in patient IPS-derived neurons. Here, we show that GP extract suppresses beta-amyloid pathology in SH-SYS5Y-APP(695) cells and APP/PS1 mice. Moreover, AMP-activated protein kinase (AMPK) activity is enhanced by GP extract in U87 cells and APP/PS1 mice. Intriguingly, GP extract enhances autophagy in SH-SYS5Y-APP(695) cells, U87 cells, and the nematode Caenorhabditis elegans, suggesting a conserved molecular mechanism by which GP extract might regulate autophagy. In agreement with its role as an autophagy activator, GP extract markedly diminishes mobility decline in polyglutamine Q35 mutants and aged wild-type N2 animals in C. elegans. Furthermore, GP extract significantly extends lifespan in C. elegans.

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