期刊
NUTRIENTS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu14030518
关键词
maternal diet; children; neurodevelopment; omega-3 fatty acids; population-based cohort
资金
- Instituto de Salud Carlos III [CP14/00108, PI16/00261, PI21/00266, Red INMA G03/176, CB06/02/0041, PI041436, PI081151, PI06/0867, FIS-PI18/01142, FIS-PI09/00090]
- European Regional Development Fund A way to make Europe
- European Social Fund Investing in your future
- Generalitat de Catalunya [CIRIT 1999SGR 00241]
- Spanish Ministry of Science and Innovation
- State Research Agency through the Centro de Excelencia Severo Ochoa 2019-2023 program [CEX2018-000806-S]
- Generalitat de Catalunya through the CERCA program
- Fundacio La marato de TV3 [090430]
- CIBERESP
- Generalitat de Catalunya-AGAUR [2009 SGR 501]
- EU Commission [261357]
- UE (FP7-ENV-2011) [282957, HEALTH.2010.2.4.5-1]
- Spain: ISCIII [Red INMA G03/176, CB06/02/0041, PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663]
- Generalitat Valenciana: FISABIO [UGP 15-230, UGP15-244, UGP-15-249]
- Alicia Koplowitz Foundation
- FEDER funds [FIS-PI042018, FIS-PI09/02311, FIS-PI13/02429, FIS-PI18/00909]
- Obra Social Cajastur/Fundacion Liberbank
- UNIVERSIDAD DE OVIEDO
- Department of Health of the Basque Government [2005111093, 2015111065]
- Provincial Government of Gipuzkoa [DFG06/002, DFG15/221]
- ICREA
- Miguel Servet-II contract by the Instituto de Salud Carlos III [CPII19/00015, CPII18/00018]
- FEDER funds
- Generalitat de Catalunya-CIRIT [1999SGR 00241]
- Spain: ISCIII (Miguel Servet-FEDER) [CP11/00178, CP15/00025, CPII16/00051]
This study found a positive association between n-3 PUFA intake during early pregnancy and neuropsychological functions in children at 4 and 7 years of age, suggesting the potential benefits of n-3 PUFAs for cognitive development.
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: -22.95, -0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings.
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