4.7 Article

Body Composition and Its Impact on the Hormonal Disturbances in Women with Polycystic Ovary Syndrome

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NUTRIENTS
卷 13, 期 12, 页码 -

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MDPI
DOI: 10.3390/nu13124217

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polycystic ovary syndrome; body composition; hormones

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This study found that women with Polycystic Ovary Syndrome (PCOS) did not show significant differences in body composition parameters compared to those without PCOS, but they had higher hormone concentrations, with sex hormone binding globulin and free testosterone correlating with all investigated body composition parameters only in the PCOS group. Additionally, logistic regression identified that the concentration of Anti-Mullerian hormones and body mass index could be useful parameters in differentiating women with PCOS from those with other disorders.ROC analysis further confirmed the concentration of Anti-Mullerian hormones as a powerful parameter for categorizing women as suffering from PCOS.
We investigated the relationship between selected body composition (BC) parameters and included 55 women diagnosed with PCOS and 29 women in which PCOS was excluded. Hormone concentration and BC parameters were assessed during hospitalization. Women with PCOS had higher concentration of luteinizing hormones, total testosterone, androstenedione, and Anti-Mullerian hormones compared to women that were not diagnosed with PCOS. We did not observe any significant differences in the BC parameters between both groups as well as between four PCOS phenotype subgroups. Only in the group of women with PCOS was the concentration of sex hormone binding globulin and free testosterone correlated with all investigated BC parameters. Correspondence analysis did not confirm unambiguously associations between phenotypes of PCOS and the value of BC parameters, while logistic regression revealed that increased Anti-Mullerian hormone concentration and the value of body mass index could be useful parameters in differentiating women with PCOS and women with other disorders. The ROC analysis performed on the entire group of women also confirmed that the concentration of Anti-Mullerian hormones could be a powerful parameter to categorize women as suffering from PCOS.

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