4.7 Article

Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects

期刊

NUTRIENTS
卷 14, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/nu14020347

关键词

vitamin D; MHR index; metabolic syndrome; gender difference

资金

  1. EU-JPI HDL-INTIMIC -MIUR FATMAL
  2. MIUR-PRIN 2017 [2017 J3E2W2]
  3. MIUR-PON R&I 2014-2020 BIOMIS [ARS01_01220]
  4. POR Puglia FESR-FSE 2014-2020, INNOMA [4TCJLV4]
  5. [PON AIM1853334]

向作者/读者索取更多资源

This study investigated the association between vitamin D levels and inflammatory status in a population of adults. The results showed an inverse relationship between vitamin D levels and the monocytes-to-high density lipoprotein ratio (MHR). When stratified by gender and body composition, men showed a significant relationship only in cases of central obesity, while women exhibited a lifelong negative correlation between circulating vitamin D levels and MHR, regardless of metabolic status.
Vitamin D deficiency is often linked with Metabolic Syndrome, both being more frequent with ageing and associated with an increase inflammatory state. Recently, monocytes-to-high density lipoprotein (HDL) ratio (MHR) has emerged as a powerful index to predict systemic inflammation. In this cross-sectional study, we investigated the association between circulating vitamin D level (25-OH vitamin D) and inflammatory status in a population of 1048 adult individuals. Our study reveals an inverse association between 25-OH vitamin D levels and MHR in the overall population. When the population is stratified by gender, waist circumference, and body mass index (BMI), we observed that while in men this relation is strongly significative only in condition of central obesity, in women a lifelong negative correlation exists between circulating 25-OH vitamin D and MHR and it is independent of the metabolic status. These observations underscore the relevance of circulating biomarkers such as MHR in the prediction of systemic inflammatory conditions sustained by vitamin D deficiency also in healthy and young women.

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