期刊
NUTRIENTS
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nu13114165
关键词
type 1 diabetes; exercise; hypoglycemia; insulin therapy; glycemic excursion; hypoglycemia treatment
资金
- Ministry of Health, Czech Republic-conceptual development of research organization, Motol University Hospital, Prague, Czech Republic [00064203]
This study characterized the glucose dynamics during standardized hypoglycemia-inducing exercise in type 1 diabetes patients and found that oral ingestion of 20 g of glucose effectively maintained recovery from hypoglycemia.
The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 & PLUSMN; 0.03 mmol/L & BULL;min(-1) (minimum: 0.07, maximum: 0.17 mmol/L & BULL;min(-1)). During recovery, ABG increased at a mean rate of 0.13 & PLUSMN; 0.05 mmol/L & BULL;min(-1) (minimum: 0.06, maximum: 0.19 mmol/L & BULL;min(-1)). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
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