4.7 Article

Oleanolic Acid-Enriched Olive Oil Alleviates the Interleukin-6 Overproduction Induced by Postprandial Triglyceride-Rich Lipoproteins in THP-1 Macrophages

期刊

NUTRIENTS
卷 13, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/nu13103471

关键词

oleanolic acid; olive oil; functional foods; postprandial trial; human triglyceride-rich lipoproteins; metabolic syndrome; obesity; insulin resistance; adolescents; THP-1 macrophages

资金

  1. Andalusia 2014-2020 European Regional Development Fund (ERDF) Operative Program [B-AGR-287-UGR18]

向作者/读者索取更多资源

Oleanolic acid (OA) can prevent metabolic syndrome by reducing inflammation and improving levels of AMPK-alpha; Functional foods enriched with OA from olive oil can significantly decrease IL-6 levels in THP-1 macrophages.
Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as a component of functional foods for the prevention of metabolic syndrome, due to its anti-inflammatory activity. We analyzed the effects of OA on inflammatory parameters and signaling proteins in LPS-stimulated THP-1 macrophages. Thus, THP-1 macrophages were incubated with LPS for 48 h after pretreatment with OA at different concentrations. Pretreatment with OA was significantly effective in attenuating IL-6 and TNF-alpha overproduction induced by LPS in macrophages, and also improved the levels of AMPK-alpha. We also evaluated the effects of human triglyceride-rich lipoproteins (TRLs) derived from individuals consuming an OA-enriched functional olive oil. For this purpose, TRLs were isolated from healthy adolescents before, 2 and 5 h postprandially after the intake of a meal containing the functional olive oil or common olive oil, and were incubated with THP-1 macrophages. THP-1 macrophages incubated with TRLs isolated at 2 h after the consumption of the OA-enriched olive oil showed significant lower levels of IL-6 compared to the TRLs derived from olive oil. Our results suggest that OA might have potential to be used as a lipid-based formulation in functional olive oils to prevent inflammatory processes underlying metabolic syndrome in adolescents.

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