期刊
MATERIALS
卷 15, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ma15031148
关键词
Mg-based alloys; orthopedy; biomaterials; mechanical properties; clinical translation; biocompatibility
类别
资金
- Romanian Ministry of Education and Research, CNCS-UEFISCDI, within PNCDI III [PN-III-P4-ID-PCE-2020-2591]
- Competitiveness Operational Program 2014-2020, Action 1.1.3: Creating synergies with RDI actions of the EU's HORIZON 2020 framework program and other international RDI programs, MySMIS [108792, 250]
This paper provides a detailed overview of the development and manufacturing techniques of magnesium-based alloys as orthopedic temporary implants. It covers the physiological and toxicological effects of alloying elements, mechanical properties, osteogenesis, angiogenesis, and biocompatibility of these alloys. The article also discusses in vitro experiments, animal testing, and clinical translation.
Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval.
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