期刊
MATERIALS
卷 15, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ma15031155
关键词
collagenous biomaterial; guided bone regeneration membrane; scanning electron microscopy; thermogravimetry-differential thermal analysis; collagenase dissolution test; subcutaneous implantation test; cross-linking of collagen fibrils
类别
资金
- JSPS KAKENHI [21K17070, 20K10015, 21K09984]
- Grants-in-Aid for Scientific Research [21K09984, 21K17070, 20K10015] Funding Source: KAKEN
This study characterized five clinically applied collagenous biomaterials using four different methods and found that membrane-type materials have longer biodegradation time and higher durability due to their higher cross-link degree. These findings are valuable for the selection and development of fibrous collagenous biomaterials.
Collagenous biomaterials that are clinically applied in dentistry have dermis-type and membrane-type, both of which are materials for promoting bone and soft tissue formation. The properties of materials supplied with different types could affect their biodegradation periods. The purpose of this study was to characterize five of these products by four different methods: scanning electron microscopy (SEM) observation, thermogravimetry-differential thermal analysis (TG-DTA), 0.01 wt% collagenase dissolution test, and subcutaneous implantation test in vivo. SEM micrographs revealed that both dermis and membranous materials were fibrous and porous. The membranous materials had higher specific derivative thermal gravimetry (DTG) peak temperatures in TG-DTA at around 320 degrees C, longer collagenase dissolution time ranging from about 300 to 500 min, and more longevity in mice exceeding 9 weeks than the dermis materials. There existed a correlation between the peak temperature in TG-DTA and the collagenase dissolution time. It was considered that higher cross-link degree among collagen fibrils of the membrane-type collagenous materials might account for these phenomena. The experimental protocol and numerical results obtained could be helpful for selection and future development of fibrous collagenous biomaterials in clinical use.
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