4.6 Article

Raman Spectroscopic Study of TiO2 Nanoparticles' Effects on the Hemoglobin State in Individual Red Blood Cells

期刊

MATERIALS
卷 14, 期 20, 页码 -

出版社

MDPI
DOI: 10.3390/ma14205920

关键词

red blood cell; hemoglobin; titanium dioxide nanoparticles; Raman spectroscopy; Raman mapping

资金

  1. Taiwan Ministry of Science and Technology [MOST 106-2112-M-259-009-MY3, MOST 109-2923-M-259-001-MY3]
  2. Russian Science foundation [20-45-08004]
  3. Russian Science Foundation [20-45-08004] Funding Source: Russian Science Foundation

向作者/读者索取更多资源

This study analyzed the interaction of titanium dioxide nanoparticles with individual rat red blood cells, finding that both types of TiO2 nanoparticles adsorbed on the RBC membrane can affect the hemoglobin state. The study also suggested potential mechanisms involving the nanoparticles-membrane-hemoglobin interaction, resulting in partial deoxygenation of hemoglobin and TiO2 photothermal effect on hemoglobin.
Titanium dioxide (TiO2) is considered to be a nontoxic material and is widely used in a number of everyday products, such as sunscreen. TiO2 nanoparticles (NP) are also considered as prospective agents for photodynamic therapy and drug delivery. These applications require an understanding of the potential effects of TiO2 on the blood system and its components upon administration. In the presented work, we analyze the interaction of TiO2 nanoparticles of different crystal phases (anatase and rutile) with individual rat Red Blood Cells (RBC) and the TiO2 influence on the oxygenation state and functionality of RBC, estimated via analysis of Raman spectra of Hemoglobin (Hb) and their distribution along individual RBC. Raman spectral signals also allow localization of the TiO2 NP on the RBC. No penetration of the NP inside RBC was observed; however, both kinds of TiO2 NP adsorbed on the RBC membrane can affect the Hb state. Mechanisms involving the NP-membrane-Hb interaction, resulting in partial deoxygenation of Hb and TiO2 photothermal effect on Hb under Raman laser excitation, are suggested. The possible influence on the safety of TiO2 use in advanced medical application, especially on the safety and efficiency of photothermal therapy, is discussed.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据