Stationary Phases for Green Liquid Chromatography

Industrial research, including pharmaceutical research, is increasingly using liquid chromatography techniques. This involves the production of large quantities of hazardous and toxic organic waste. Therefore, it is essential at this point to focus interest on solutions proposed by so-called green chemistry. One such solution is the search for new methods or the use of new materials that will reduce waste. One of the most promising ideas is to perform chromatographic separation using pure water, without organic solvents, as a mobile phase. Such an approach requires novel stationary phases or specific chromatographic conditions, such as an elevated separation temperature. The following review paper aims to gather information on stationary phases used for separation under purely aqueous conditions at various temperatures.

Automated summary

Industrial research, including pharmaceutical research, is using liquid chromatography techniques more frequently. However, the generation of large quantities of hazardous and toxic organic waste has become a concern. In response, green chemistry proposes solutions such as using pure water as a mobile phase for chromatographic separation, which requires new stationary phases or specific chromatographic conditions.