期刊
MATERIALS
卷 14, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ma14216531
关键词
hydrophilic matrix tablets; sustained release drug delivery; sodium alginate; polymer hydration; swelling; drug solubility; polymer dissolution; magnetic resonance imaging; mass transport; X-ray microtomography
类别
资金
- Polish National Centre for Research and Development (NCBR) [POIR.04.01.04-00-0142/17]
The study demonstrated the unique hydration patterns of polymer-based matrices, showing features such as internal locking, lamellar regions, water resolution, and water penetration. These patterns were influenced by matrix composition and molecular properties of constituents.
The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., locking of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.
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