Synthesis of benzimidazole by mortar-pestle grinding method

An environmentally friendly and efficient protocol for the synthesis of benzimidazoles by mortar-pestle grinding technique in the presence of acetic acid as a catalyst is reported. This mechanochemical method proceeded with the condensation of aldehyde and o-phenylenediamine followed by cyclization reaction, leading to the formation of the corresponding benzimidazoles in yields up to 97%. This protocol could also be applied for the synthesis of benzothiazoles and benzoxazoles.

Automated summary

An environmentally friendly and efficient protocol for the synthesis of benzimidazoles using mortar-pestle grinding technique in the presence of acetic acid as a catalyst is reported. The mechanochemical method involves the condensation of aldehyde and o-phenylenediamine followed by cyclization reaction, leading to high yields up to 97%. This protocol is also applicable for the synthesis of benzothiazoles and benzoxazoles.