期刊
FRONTIERS IN NEUROANATOMY
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnana.2021.764458
关键词
fractone; heparan sulfate chains; neurogenesis; subventricular zones; extracellular matrix; growth factors; glycosaminoglycans
资金
- JSPS KAKENHI [20K08089, 18K07535]
- Grants-in-Aid for Scientific Research [20K08089, 18K07535] Funding Source: KAKEN
This review summarizes the current understanding of the extracellular matrix (ECM) niche in the adult subventricular zone (SVZ) of the mammalian brain, with a focus on how basement membrane-like structures called fractones, and their composition of glycosaminoglycans (GAGs), may impact neurogenesis by regulating growth factor signaling pathways.
In the adult mammalian brain, new neurons are generated in a restricted region called the neurogenic niche, which refers to the specific regulatory microenvironment of neural stem cells (NSCs). Among the constituents of neurogenic niches, the extracellular matrix (ECM) has emerged as a key player in NSC maintenance, proliferation, and differentiation. In particular, heparan sulfate (HS) proteoglycans are capable of regulating various growth factor signaling pathways that influence neurogenesis. In this review, we summarize our current understanding of the ECM niche in the adult subventricular zone (SVZ), with a special focus on basement membrane (BM)-like structures called fractones, and discuss how fractones, particularly their composition of glycosaminoglycans (GAGs), may influence neurogenesis.
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