期刊
FOOD & FUNCTION
卷 13, 期 5, 页码 2534-2544出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo03697a
关键词
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资金
- National Natural Science Foundation of China project [32072242, 32102012]
- National Key R&D Program of China [2018YFD0401200]
- First-class Discipline Project of Liaoning Province [LSPBD20313]
- Special Action Plan for Science & Technology Program [2020JH5/10400009]
This study successfully fabricated a high internal phase Pickering emulsion (HIPPE) using meat protein and olive oil, which co-encapsulated puerarin and beta-carotene, leading to improved bioaccessibility of puerarin. In addition, it was found that the HIPPE slowed down lipid digestion and inhibited puerarin degradation, indicating a synergistic interaction between beta-carotene and the HIPPE.
Puerarin, a bioactive flavonoid found in the root of Pueraria lobata, is claimed to possess various medicinal properties. However, application of puerarin in functional foods is currently limited by its poor bioaccessibility. Existing delivery systems that guarantee puerarin bioaccessibility involve complex preparation steps and safety issues. Therefore, this study aimed to use meat protein and olive oil to efficiently and economically fabricate a food grade high internal phase Pickering emulsion (HIPPE) with co-encapsulated puerarin and beta-carotene to improve the bioaccessibility of puerarin. Moreover, the impact on lipid digestibility and puerarin bioaccessibility was verified using a simulated in vitro gastrointestinal tract. Co-encapsulating puerarin and beta-carotene in HIPPE increased puerarin bioaccessibility (85.17%) compared to that achieved with only puerarin in HIPPE (62.66%). This increased bioaccessibility may have been due to the personalized formulation and the exceptional structure of the HIPPE, which slowed down lipid digestion and inhibited puerarin degradation. A synergistic interaction occurred between beta-carotene and HIPPE to improve puerarin bioaccessibility. Our results have important implications for the design of effective delivery systems for encapsulation of puerarin and other bioactive components.
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