期刊
FOOD & FUNCTION
卷 13, 期 5, 页码 2865-2883出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo03888e
关键词
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资金
- National Natural Science Foundation of China [32101968]
- National Key Research and Development Program of China [2017YFD0400200]
- China Postdoctoral Science Foundation [2020M683542]
- Innovative Talent Promotion Program-Technology Innovation Team [2019TD-006]
- Doctoral Research Fund in Northwest AF University [Z1090220165]
The study found that sesamol prevented inflammatory response, epithelial barrier dysfunction, and depression-like and anxiety-like behaviors in mice with DSS-induced IBD. Sesamol achieved this protective effect by suppressing neuroinflammatory responses, protecting against oxidative stress, improving BDNF levels, and restoring synaptic impairments. The gut barrier and LPS content were found to be highly associated with behavioral performance and brain biochemical indexes.
Inflammatory bowel disease (IBD) is accompanied by some psychiatric disorders, including anxiety and depression. Sesamol has been reported to alleviate colitis symptoms and depression-like behaviors caused by chronic unpredictable mild stress, but its protective effect and underlying neurobiological mechanism on IBD induced by dextran sulfate sodium (DSS) accompanying depression-like and anxiety-like behaviors remains still unclear. Here, we found that a six-week sesamol treatment (100 mg per kg bodyweight per day) for DSS-induced mice predominantly prevented inflammatory response, epithelial barrier dysfunction and depression-like and anxiety-like behaviors via the gut-brain axis. Sesamol alleviated neuroinflammatory responses via suppressing the TLR-4/NF-kappa B pathway, protected against oxidative stress and upregulated the Nrf2 antioxidant signaling pathway. Moreover, sesamol treatment improved brain-derived neurotrophic factor (BDNF) by upregulating the BDNF/TrkB/CREB signaling pathway, restored synaptic impairments and enhanced norepinephrine (NE) and serotonin (5-HT) levels. Importantly, the correlation analysis showed that the gut barrier and lipopolysaccharide (LPS) content in the serum were highly associated with behavioral performance and the biochemical indexes of the brain. In summary, the present study indicates that sesamol is a novel nutritional intervention strategy for preventing IBD and its symptoms of anxiety and depression.
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