期刊
FOOD & FUNCTION
卷 13, 期 2, 页码 639-648出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo03234h
关键词
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资金
- KAKENHI [15K14725]
- Asahi Group Foundation, Ltd.
- Japan Society for the Promotion of Science (JSPS) [201921566]
- Grants-in-Aid for Scientific Research [15K14725] Funding Source: KAKEN
The study found that some food compounds binding stronger to albumin than curcumin can enhance the physiological activity of curcumin. Experimental results confirmed this hypothesis, providing insights into enhancing the physiological activities of various food compounds by focusing on their interaction with albumin.
Based on the free drug hypothesis, we hypothesized that food compounds that bind stronger to BSA than CUR inhibit the binding between BSA and CUR, and that this results in an increase of the cellular uptake and physiological activities of CUR. To verify this hypothesis, food compounds that bind stronger to BSA than CUR were identified. When THP-1 monocytes were co-treated with the identified compounds (e.g., piperine) and CUR, cell viability significantly decreased, suggesting that the physiological activity of CUR was enhanced. Also, when THP-1 macrophages were co-treated with CUR and the identified compounds following LPS + IFN gamma treatment, the decrement of TNF-alpha was higher compared to treatment with CUR only. Furthermore, the cellular uptake of CUR was increased during this co-treatment. Such results verify our hypothesis, and provide insights into the development of ways to enhance the physiological activities of various food compounds via focusing on their interaction with albumin.
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