期刊
CATALYSIS SCIENCE & TECHNOLOGY
卷 12, 期 5, 页码 1392-1399出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cy02017j
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资金
- Deutsche Forschungsgemeinschaft (DFG)
A new set of hybrid P-stereogenic phosphine-diamidophosphite ligands based on the Betti base backbone has been synthesized and applied in Rh-catalyzed asymmetric hydrogenation and Pd-catalzyed asymmetric allylic substitution reactions. Moderate enantioselectivities up to 74% in allylic substitution and excellent enantioselectivities up to 99% in asymmetric hydrogenation were achieved using these new ligands.
A set of hybrid P-stereogenic phosphine-diamidophosphite ligands based on the Betti base backbone has been synthesized. The ligands possess five chiral centers including the P-chirality in both the phosphorus atoms. The synthesis involves the incorporation of a P-chiral P-N synthon with a stereochemically defined P-chiral diamidophosphite as a coupling partner. The new ligands were applied in Rh-catalyzed asymmetric hydrogenation of several dehydroamino acids and in the Pd-catalzyed asymmetric allylic substitution of diphenyl allyl acetate. Moderate ees upto 74% in allylic substitution and excellent ees up to 99% were obtained in asymmetric hydrogenation using this new set of hybdrid PNP ligands.
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