4.5 Article

Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

期刊

BMC PREGNANCY AND CHILDBIRTH
卷 21, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12884-021-04154-0

关键词

Life events; Congenital heart disease; Case-control study

资金

  1. Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning [Sxwsjswzfcght2016-013]
  2. National Natural Science Foundation of China [81230016]

向作者/读者索取更多资源

The study suggests that maternal exposure to negative life events during pregnancy may increase the risk of congenital heart disease in offspring, while experiencing positive events may have a potential protective role.
Background Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring. Methods The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed acyclic graph was drawn to screen the confounders. Logistic regression was employed to estimate the odds ratio and 95% confidence interval for the effects of life events on CHD. Results After controlling for the potential confounders, the pregnant women experiencing the positive events during pregnancy had lower risk of CHD in offspring than those without positive events (OR = 0.38, 95%CI: 0.30 similar to 0.48). The risk of CHD in offspring could increase by 62% among the pregnant women experiencing the negative events compared to those without (OR = 1.62, 95%CI: 1.29 similar to 2.03). Both effects showed a certain dose-response association. Besides, the positive events could weaken the risk impact of negative events on CHD. Conclusion It may suggest that maternal exposure to negative life events could increase the risk of CHD in offspring, while experiencing positive events could play a potential protective role.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据