4.6 Article

Suppression of the non-linear background in a multimode fibre CARS endoscope

期刊

BIOMEDICAL OPTICS EXPRESS
卷 13, 期 2, 页码 862-874

出版社

OPTICAL SOC AMER
DOI: 10.1364/BOE.450375

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资金

  1. Akademie Ved Ceske Republiky [RVO:68081731]
  2. European Research Council [724530]
  3. European Regional Development Fund [CZ.02.1.01/0.0/0.0/15_003/0000476]
  4. Ministerstvo Skolstvi, Mladeze a Telovychovy [CZ.02.1.01/0.0/0.0/16_013/0001775, CZ.02.1.01/0.0/0.0/18_046/0016045, LM2018129]

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Multimode fibres have potential as miniature endoscopes for deep tissue imaging. Using a composite probe consisting of a GRIN fibre and a spliced on step-index fibre reduces the intensity of the non-linear background signal.
Multimode fibres show great potential for use as miniature endoscopes for imaging deep in tissue with minimal damage. When used for coherent anti-Stokes Raman scattering (CARS) microscopy with femtosecond excitation sources, a high band-width probe is required to efficiently focus the broadband laser pulses at the sample plane. Although graded-index (GRIN) fibres have a large bandwidth, it is accompanied by a strong background signal from four-wave mixing and other non-linear processes occurring inside the fibre. We demonstrate that using a composite probe consisting of a GRIN fibre with a spliced on step-index fibre reduces the intensity of the non-linear background by more than one order of magnitude without significantly decreasing the focusing performance of the probe. Using this composite probe we acquire CARS images of biologically relevant tissue such as myelinated axons in the brain with good contrast. (c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

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