期刊
ACS CATALYSIS
卷 11, 期 21, 页码 13028-13033出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c04070
关键词
halogen bonding; asymmetric catalysis; chiral bromonium salt; Mannich reaction; DFT calculation
资金
- JSPS [20K15271]
- Leading Research Promotion Program Soft Molecular Activation of Chiba University, Japan
- Grants-in-Aid for Scientific Research [20K15271] Funding Source: KAKEN
This study reports the design and development of chiral cyclic diarylbromonium salts, enabling highly selective Lewis acid XB catalysis with products reaching up to 96% ee.
Bromonium salts, which are hypervalent bromine reagents, have been explored as being strong electrophiles owing to their extremely high nucleofugalities. Only one example of their catalytic application has been reported by our group; however, their chiral versions have not yet been researched. Halogen-bonding (XB) has been widely applied in chemistry; however, its successful application to highly enantioselective Lewis acid catalysis has not yet been achieved. Herein, we report the design and development of chiral cyclic diarylbromonium salts. These catalysts enabled a highly enantioselective Lewis acid XB catalysis, giving products with up to 96% ee.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据