期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-26497-0
关键词
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资金
- LabEx CeMEB
- ANR 'Investissements d'avenir' programme [ANR-10-LABX-04-01]
- 'Bio-Environnement' platform at the University of Perpignan Via Domitia
- FundacAo de Amparo a Pesquisa do Estado de SAo Paulo (FAPESP) [15/06366-2, 18/15049-9, 18/23693-5]
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil - Finance [001, 19/09404-3, 16/10046-6, 18/18117-5]
- EPICURE (projet de recherche conjoints CNRS Bresil FAPESP - 2018)
- FundacAo Butantan
- CNPq, Brazil
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/23693-5, 18/15049-9] Funding Source: FAPESP
The study characterized the self-cure process of rhesus macaques following Schistosoma mansoni infection, showing that established infection can be cleared and resistance to reinfection can be developed. Cultured schistosomula were killed by rhesus plasma, suggesting practical applications in developing an effective vaccine.
To date there is only one single drug with modest efficacy and no vaccine available to protect from schistosomiasis. Here, Amaral et al. characterize the self-cure process of rhesus macaques following primary infection and secondary challenge with Schistosoma mansoni to inform future vaccine development studies. The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict >200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an established infection with Schistosoma mansoni is cleared in an exponential manner, eliciting resistance to reinfection. Secondary challenge at week 42 demonstrates that protection is strong in all animals and complete in some. Antibody profiles suggest that antigens mediating protection are the released products of developing schistosomula. In culture they are killed by addition of rhesus plasma, collected from week 8 post-infection onwards, and even more efficiently with post-challenge plasma. Furthermore, cultured schistosomula lose chromatin activating marks at the transcription start site of genes related to worm development and show decreased expression of genes related to lysosomes and lytic vacuoles involved with autophagy. Overall, our results indicate that enhanced antibody responses against the challenge migrating larvae mediate the naturally acquired protective immunity and will inform the route to an effective vaccine.
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