相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma
Ivette Valencia-Sama et al.
CANCER RESEARCH (2020)
KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer
Zhi-Wei Zhou et al.
CANCER RESEARCH (2020)
Scalable molecular dynamics on CPU and GPU architectures with NAMD
James C. Phillips et al.
JOURNAL OF CHEMICAL PHYSICS (2020)
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Abimael Cruz-Migoni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction
Roman C. Hillig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors
Hengyu Lu et al.
MOLECULAR CANCER THERAPEUTICS (2019)
Conformational and Dynamical Effects of Tyr32 Phosphorylation in K-Ras: Molecular Dynamics Simulation and Markov State Models Analysis
Mohammed Khaled et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2019)
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Yoshihito Kano et al.
NATURE COMMUNICATIONS (2019)
SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
Tamer A. Ahmed et al.
CELL REPORTS (2019)
Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer
John H. Strickler et al.
CANCER DISCOVERY (2018)
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
Matthew R. Janes et al.
CELL (2018)
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
Dietrich A. Ruess et al.
NATURE MEDICINE (2018)
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Gabrielle S. Wong et al.
NATURE MEDICINE (2018)
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo
Sara Mainardi et al.
NATURE MEDICINE (2018)
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
Leila Dardaei et al.
NATURE MEDICINE (2018)
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1-and RAS-driven cancers
Robert J. Nichols et al.
NATURE CELL BIOLOGY (2018)
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
Carmine Fedele et al.
CANCER DISCOVERY (2018)
KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer
Stephane Renaud et al.
ONCOTARGET (2017)
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Ying-Nan P. Chen et al.
NATURE (2016)
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey et al.
NATURE (2016)
Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis
Lian-yuan Tao et al.
WORLD JOURNAL OF SURGICAL ONCOLOGY (2016)
Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
Jacob J. Chabon et al.
NATURE COMMUNICATIONS (2016)
KRAS Engages AGO2 to Enhance Cellular Transformation
Sunita Shankar et al.
CELL REPORTS (2016)
KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma
Barbara Bournet et al.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2016)
Third-generation epidermal growth factor receptor-tyrosine kinase inhibitors in T790M-positive non-small cell lung cancer: review on emerged mechanisms of resistance
Roberta Minari et al.
TRANSLATIONAL LUNG CANCER RESEARCH (2016)
A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer
J. S. Chen et al.
ANNALS OF ONCOLOGY (2015)
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj et al.
CELL (2015)
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
Richard A. Moffitt et al.
NATURE GENETICS (2015)
The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS
James M. Aramini et al.
STRUCTURE (2015)
Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
Susan K. Fetics et al.
STRUCTURE (2015)
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Severa Bunda et al.
NATURE COMMUNICATIONS (2015)
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Agnieszka K. Witkiewicz et al.
NATURE COMMUNICATIONS (2015)
NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
Woonghee Lee et al.
BIOINFORMATICS (2015)
Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer
Kyle Knickelbein et al.
GENES & DISEASES (2015)
Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate
Maria G. Khrenova et al.
BIOCHEMISTRY (2014)
Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
Li-Fan Zeng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation
Severa Bunda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
John C. Hunter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
RAS Mutation Status Predicts Survival and Patterns of Recurrence in Patients Undergoing Hepatectomy for Colorectal Liver Metastases
Jean-Nicolas Vauthey et al.
ANNALS OF SURGERY (2013)
The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein
Yoshihito Kano et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
NMR-based functional profiling of RASopathies and oncogenic RAS mutations
Matthew J. Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A Comprehensive Survey of Ras Mutations in Cancer
Ian A. Prior et al.
CANCER RESEARCH (2012)
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone φ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
Robert B. Best et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts
Christopher B. Marshall et al.
METHODS (2012)
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
William E. Tidyman et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)
The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
Marie Dance et al.
CELLULAR SIGNALLING (2008)
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
Benjamin Stieglitz et al.
EMBO JOURNAL (2008)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
GEFs and GAPs: Critical elements in the control of small G proteins
Johannes L. Bos et al.
CELL (2007)
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases
MA Seeliger et al.
PROTEIN SCIENCE (2005)
A novel role for Gab1 and SHP2 in epidermal growth factor-induced ras activation
A Montagner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Improved treatment of the protein backbone in empirical force fields
AD MacKerell et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
YM Agazie et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
BE Hall et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP
H Resat et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Structural changes induced in p21Ras upon GAP-334 complexation as probed by ESEEM spectroscopy and molecular-dynamics simulation
CT Farrar et al.
STRUCTURE (2000)
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
ME Pacold et al.
CELL (2000)
How does GAP catalyze the GTPase reaction of Ras?:: A computer simulation study
TM Glennon et al.
BIOCHEMISTRY (2000)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
M Ohh et al.
NATURE CELL BIOLOGY (2000)
分享论文
