期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-27963-z
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资金
- US National Science Foundation, Division of Astronomical Sciences [AST-1800975, AST-2103269]
- University of Hawaii
- NASA [NNX17AH15G]
- University of Mississippi
- NSF [CHE-CHE-1338056, OIA-1757220]
The Strecker synthesis is a viable route to amino acids formation on the primordial Earth. The authors successfully observed the elusive intermediate aminomethanol in the reaction and discovered its unexpected kinetic stability in extreme environments. This finding changes our understanding of the synthetic pathways to amino acids.
The Strecker synthesis is considered a viable route to amino acids formation on the primordial Earth. Here the authors succeed in observing its elusive intermediate aminomethanol, formed by insertion of an electronically excited oxygen atom in methylamine and stabilized by an icy matrix, using isomer-selective photoionization time-of-flight mass spectrometry during thermal desorption of the ice mixture. The Strecker Synthesis of (a)chiral alpha-amino acids from simple organic compounds, such as ammonia (NH3), aldehydes (RCHO), and hydrogen cyanide (HCN) has been recognized as a viable route to amino acids on primordial earth. However, preparation and isolation of the simplest hemiaminal intermediate - the aminomethanol (NH2CH2OH)- formed in the Strecker Synthesis to even the simplest amino acid glycine (H2NCH2COOH) has been elusive. Here, we report the identification of aminomethanol prepared in low-temperature methylamine (CH3NH2) - oxygen (O-2) ices upon exposure to energetic electrons. Isomer-selective photoionization time-of-flight mass spectrometry (PI-ReTOF-MS) facilitated the gas phase detection of aminomethanol during the temperature program desorption (TPD) phase of the reaction products. The preparation and observation of the key transient aminomethanol changes our perception of the synthetic pathways to amino acids and the unexpected kinetic stability in extreme environments.
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