Nationally representative SARS-CoV-2 antibody prevalence estimates after the first epidemic wave in Mexico

Seroprevalence surveys provide estimates of the extent of SARS-CoV-2 infections in the population, regardless of disease severity and test availability. In Mexico in 2020, COVID-19 cases reached a maximum in July and December. We aimed to estimate the national and regional seroprevalence of SARS-CoV-2 antibodies across demographic and socioeconomic groups in Mexico after the first wave, from August to November 2020. We used nationally representative survey data including 9,640 blood samples. Seroprevalence was estimated by socioeconomic and demographic characteristics, adjusting by the sensitivity and specificity of the immunoassay test. The national seroprevalence of SARS-CoV-2 antibodies was 24.9% (95%CI 22.2, 26.7), being lower for adults 60 years and older. We found higher seroprevalence among urban and metropolitan areas, low socioeconomic status, low education and workers. Among seropositive people, 67.3% were asymptomatic. Social distancing, lockdown measures and vaccination programs need to consider that vulnerable groups are more exposed to the virus and unable to comply with lockdown measures.

Automated summary

This study estimated the national and regional seroprevalence of SARS-CoV-2 antibodies in Mexico after the first wave from August to November 2020. The national seroprevalence was 24.9%, with lower rates among adults aged 60 and older. Higher seroprevalence was found in urban and metropolitan areas, low socioeconomic status, low education levels, and among workers. Among those with antibodies, 67.3% were asymptomatic. These findings highlight the importance of considering vulnerable groups in social distancing, lockdown measures, and vaccination programs.