期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-26002-7
关键词
-
资金
- Projekt DEAL
The study presents an efficient method for preparing asymmetric phosphines from white phosphorus, utilizing a transition metal-mediated reaction that allows for recycling and avoids the use of hazardous chemicals.
The synthesis of phosphines is based on white phosphorus, which is usually converted to PCl3, to be afterwards substituted step by step in a non-atomic efficient manner. Herein, we describe an alternative efficient transition metal-mediated process to form asymmetrically substituted phosphines directly from white phosphorus (P-4). Thereby, P-4 is converted to [Cp*Fe(eta(5)-P-5)] (1) (Cp* = eta(5)-C-5(CH3)(5)) in which one of the phosphorus atoms is selectively functionalized to the 1,1-diorgano-substituted complex [Cp*Fe(eta(4)-P5R ' R '')] (3). In a subsequent step, the phosphine PR ' R '' R' (R ' not equal R '' not equal R' = alky, aryl) (4) is released by reacting it with a nucleophile R'M (M = alkali metal) as racemates. The starting material 1 can be regenerated with P-4 and can be reused in multiple reaction cycles without isolation of the intermediates, and only the phosphine is distilled off. Asymmetrically substituted phosphine ligands play a decisive role in catalysis, but their synthesis is rather challenging and often involves hazardous chemicals such as PCl3 or PH3. Here, the authors report the one-pot preparation of asymmetric phosphines from white phosphorus via a pentaphosphaferrocene based modular system, in which the transition metal complex can be reused.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据