相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Immunogenicity of Cas9 Protein
Aditi Mehta et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2020)
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
Majda Bratovic et al.
NATURE CHEMICAL BIOLOGY (2020)
The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
Alan S. Wang et al.
MOLECULAR CELL (2020)
The delivery challenge: fulfilling the promise of therapeutic genome editing
Joost van Haasteren et al.
NATURE BIOTECHNOLOGY (2020)
Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance
Kesavan Babu et al.
BIOCHEMISTRY (2019)
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Tony P. Huang et al.
NATURE BIOTECHNOLOGY (2019)
Software tools for automated transmission electron microscopy
Martin Schorb et al.
NATURE METHODS (2019)
Origins and evolution of CRISPR-Cas systems
Eugene Koonin et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)
AAV-based gene therapies for the muscular dystrophies
Julie M. Crudele et al.
HUMAN MOLECULAR GENETICS (2019)
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
Benjamin L. Oakes et al.
CELL (2019)
Circular permutation profiling by deep sequencing libraries created using transposon mutagenesis
Joshua T. Atkinson et al.
NUCLEIC ACIDS RESEARCH (2018)
Rational Design of Mini-Cas9 for Transcriptional Activation
Dacheng Ma et al.
ACS SYNTHETIC BIOLOGY (2018)
Hybridization Kinetics Explains CRISPR-Cas Off-Targeting Rules
Misha Klein et al.
CELL REPORTS (2018)
Cas9 immunity creates challenges for CRISPR gene editing therapies
Julie M. Crudele et al.
NATURE COMMUNICATIONS (2018)
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen et al.
NATURE (2017)
Structural insights into DNA cleavage activation of CRISPR-Cas9 system
Cong Huai et al.
NATURE COMMUNICATIONS (2017)
Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering
Sean A. Higgins et al.
ACS SYNTHETIC BIOLOGY (2017)
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
Yavuz S. Dagdas et al.
SCIENCE ADVANCES (2017)
Diversity, classification and evolution of CRISPR-Cas systems
Eugene V. Koonin et al.
CURRENT OPINION IN MICROBIOLOGY (2017)
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
Britt Adamson et al.
CELL (2016)
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
Benjamin L. Oakes et al.
NATURE BIOTECHNOLOGY (2016)
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Fuguo Jiang et al.
SCIENCE (2016)
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
Max A. Horlbeck et al.
ELIFE (2016)
Crystal Structure of Staphylococcus aureus Cas9
Hiroshi Nishimasu et al.
CELL (2015)
Sequence determinants of improved CRISPR sgRNA design
Han Xu et al.
GENOME RESEARCH (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Rational design of a split-Cas9 enzyme complex
Addison V. Wright et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
Fuguo Jiang et al.
SCIENCE (2015)
Domain atrophy creates rare cases of functional partial protein domains
Ananth Prakash et al.
GENOME BIOLOGY (2015)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
Carolin Anders et al.
NATURE (2014)
Programmable RNA recognition and cleavage by CRISPR/Cas9
Mitchell R. O'Connell et al.
NATURE (2014)
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Samuel H. Sternberg et al.
NATURE (2014)
Deep mutational scanning: a new style of protein science
Douglas M. Fowler et al.
NATURE METHODS (2014)
Classification and evolution of type II CRISPR-Cas systems
Krzysztof Chylinski et al.
NUCLEIC ACIDS RESEARCH (2014)
Random Single Amino Acid Deletion Sampling Unveils Structural Tolerance and the Benefits of Helical Registry Shift on GFP Folding and Structure
James A. J. Arpino et al.
STRUCTURE (2014)
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi et al.
CELL (2013)
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
Matthew H. Larson et al.
NATURE PROTOCOLS (2013)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Hot Spots for Allosteric Regulation on Protein Surfaces
Kimberly A. Reynolds et al.
CELL (2011)
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
Ekaterina Semenova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Deep mutational scanning: assessing protein function on a massive scale
Carlos L. Araya et al.
TRENDS IN BIOTECHNOLOGY (2011)
Effect of Genome Size on AAV Vector Packaging
Zhijian Wu et al.
MOLECULAR THERAPY (2010)
BioNumbers-the database of key numbers in molecular and cell biology
Ron Milo et al.
NUCLEIC ACIDS RESEARCH (2010)
Reducing the Immunogenicity of Protein Therapeutics
Masanori Onda
CURRENT DRUG TARGETS (2009)
Evolution of protein domain promiscuity in eukaryotes
Malay Kumar Basu et al.
GENOME RESEARCH (2008)
Multicopy plasmid modification with phage λ red recombineering
Lynn C. Thomason et al.
PLASMID (2007)
Investigating protein structural plasticity by surveying the consequence of an amino acid deletion from TEM-1 β-lactamase
Alan M. Simm et al.
FEBS LETTERS (2007)
Probing the structural plasticity of an archaeal primordial cobaltochelatase CbiXS
Alexander Pisarchik et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2007)
Modeling the evolution of protein domain architectures using maximum parsimony
Jessica H. Fong et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
The folding and evolution of multidomain proteins
Jung-Hoon Han et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Domain deletions and substitutions in the modular protein evolution
J Weiner et al.
FEBS JOURNAL (2006)
Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabilization of β-lactamase
J Hecky et al.
BIOCHEMISTRY (2005)
Packaging capacity of adeno-associated virus serotypes: Impact of larger genomes on infectivity and postentry steps
JC Grieger et al.
JOURNAL OF VIROLOGY (2005)
Triplet nucleotide removal at random positions in a target gene: the tolerance of TEM-1 beta-lactamase to an amino acid deletion
DD Jones
NUCLEIC ACIDS RESEARCH (2005)
Structure, function and evolution of multidomain proteins
C Vogel et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)
Creation of an allosteric enzyme by domain insertion
G Guntas et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
JE Dueber et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)
Increase of functional diversity by alternative splicing
EV Kriventseva et al.
TRENDS IN GENETICS (2003)
Domain combinations in archaeal, eubacterial and eukaryotic proteomes
G Apic et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Fold change in evolution of protein structures
NV Grishin
JOURNAL OF STRUCTURAL BIOLOGY (2001)
The impact of comparative genomics on our understanding of evolution
EV Koonin et al.
CELL (2000)
分享论文
