相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Genome-wide detection and analysis of CRISPR-Cas off-targets
Tomas C. Rodriguez et al.
REPROGRAMMING THE GENOME: CRISPR-CAS-BASED HUMAN DISEASE THERAPY (2021)
The promise and challenge of therapeutic genome editing
Jennifer A. Doudna
NATURE (2020)
DolphinNext: a distributed data processing platform for high throughput genomics
Onur Yukselen et al.
BMC GENOMICS (2020)
A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure
Ryan P. Ceddia et al.
CLINICAL SCIENCE (2020)
Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins
Rih-Sheng Huang et al.
FRONTIERS IN IMMUNOLOGY (2020)
Cancer immunotherapy comes of age and looks for maturity
Amanda Finck et al.
NATURE COMMUNICATIONS (2020)
Proof-of-concept for CRISPR/Cas9 gene editing in human preadipocytes: Deletion of FKBP5 and PPARG and effects on adipocyte differentiation and metabolism
Prasad G. Kamble et al.
SCIENTIFIC REPORTS (2020)
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Chih-Hao Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473
Khanh-Van Tran et al.
NATURE METABOLISM (2020)
CRISPResso2 provides accurate and rapid genome editing sequence analysis
Kendell Clement et al.
NATURE BIOTECHNOLOGY (2019)
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Yuxuan Wu et al.
NATURE MEDICINE (2019)
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Carsten T. Charlesworth et al.
NATURE MEDICINE (2019)
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Jan-Bernd Funcke et al.
JOURNAL OF LIPID RESEARCH (2019)
The beneficial effects of brown adipose tissue transplantation
Joseph D. White et al.
MOLECULAR ASPECTS OF MEDICINE (2019)
The role of brown and beige adipose tissue in glycaemic control
Katarina Klepac et al.
MOLECULAR ASPECTS OF MEDICINE (2019)
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance
Jee Young Chung et al.
GENOME RESEARCH (2019)
DEBrowser: interactive differential expression analysis and visualization tool for count data
Alper Kucukural et al.
BMC GENOMICS (2019)
The integrative biology of type 2 diabetes
Michael Roden et al.
NATURE (2019)
Mesenchymal stem cell perspective: cell biology to clinical progress
Mark F. Pittenger et al.
NPJ REGENERATIVE MEDICINE (2019)
A novel brown adipocyte-enriched long non-coding RNA that is required for brown adipocyte differentiation and sufficient to drive thermogenic gene program in white adipocytes
Yan Xiong et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis
Leslie S. Kean
BLOOD (2018)
An Integrated View of Immunometabolism
Yun Sok Lee et al.
CELL (2018)
The Biology of CRISPR-Cas: Backward and Forward
Frank Hille et al.
CELL (2018)
Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN
Christian Hinderer et al.
HUMAN GENE THERAPY (2018)
Mechanisms of NAFLD development and therapeutic strategies
Scott L. Friedman et al.
NATURE MEDICINE (2018)
A direct tissue-grafting approach to increasing endogenous brown fat
Nicole R. Blumenfeld et al.
SCIENTIFIC REPORTS (2018)
Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles
Yiming Cheng et al.
CELL REPORTS (2018)
CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure
Yuefei Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
Christopher A. Vakulskas et al.
NATURE MEDICINE (2018)
Brown adipose tissue as a secretory organ
Francesc Villarroya et al.
NATURE REVIEWS ENDOCRINOLOGY (2017)
Insulin action and resistance in obesity and type 2 diabetes
Michael P. Czech
NATURE MEDICINE (2017)
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Matthew D. Lynes et al.
NATURE MEDICINE (2017)
Regulation of hepatic glucose metabolism in health and disease
Max C. Petersen et al.
NATURE REVIEWS ENDOCRINOLOGY (2017)
Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders
Zhimin Chen et al.
MOLECULAR METABOLISM (2017)
GUIDEseq: a bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases
Lihua Julie Zhu et al.
BMC GENOMICS (2017)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice
So Yun Min et al.
NATURE MEDICINE (2016)
Targeting adipose tissue in the treatment of obesity-associated diabetes
Christine M. Kusminski et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Brown and Beige Fat: Physiological Roles beyond Heat Generation
Shingo Kajimura et al.
CELL METABOLISM (2015)
Adoptive cell transfer as personalized immunotherapy for human cancer
Steven A. Rosenberg et al.
SCIENCE (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
Sangsu Bae et al.
BIOINFORMATICS (2014)
Trimmomatic: a flexible trimmer for Illumina sequence data
Anthony M. Bolger et al.
BIOINFORMATICS (2014)
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
Sojung Kim et al.
GENOME RESEARCH (2014)
The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
Guo-Xiao Wang et al.
NATURE MEDICINE (2014)
Easy quantitative assessment of genome editing by sequence trace decomposition
Eva K. Brinkman et al.
NUCLEIC ACIDS RESEARCH (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
Bi-directional interconversion of brite and white adipocytes
Matthias Rosenwald et al.
NATURE CELL BIOLOGY (2013)
Distinct functions for RIP140 in development, inflammation, and metabolism
Jaya Nautiyal et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu et al.
CELL (2012)
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Guangchuang Yu et al.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Bo Li et al.
BMC BIOINFORMATICS (2011)
The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions
Jan Nedergaard et al.
CELL METABOLISM (2010)
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Thien T. Tran et al.
NATURE REVIEWS ENDOCRINOLOGY (2010)
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
Steffen Durinck et al.
NATURE PROTOCOLS (2009)
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
AM Powelka et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
S Durinck et al.
BIOINFORMATICS (2005)
Nuclear receptor corepressor RIP140 regulates fat accumulation
G Leonardsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)