Clinical outcomes and cost-effectiveness of COVID-19 vaccination in South Africa

Article Medicine, General & Internal

College Campuses and COVID-19 Mitigation: Clinical and Economic Value

Elena Losina et al.

Summary: The study found that implementing strict social distancing and mask policies on college campuses can effectively prevent COVID-19 cases, while routine laboratory testing can further reduce infection rates and is very cost-effective.

ANNALS OF INTERNAL MEDICINE (2021)

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Letter Medicine, General & Internal

Speed Versus Efficacy: Quantifying Potential Tradeoffs in COVID-19 Vaccine Deployment

A. David Paltiel et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Health Care Sciences & Services

Clinical Outcomes Of A COVID-19 Vaccine: Implementation Over Efficacy

A. David Paltiel et al.

Summary: Implementation factors play a crucial role in the success of vaccination programs, outweighing vaccine efficacy determined in clinical trials. Manufacturing or deployment delays, vaccine hesitancy, and increased epidemic severity can significantly diminish the benefits of a vaccine.

HEALTH AFFAIRS (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Medicine, General & Internal

Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence

Ester C. Sabino et al.

LANCET (2021)

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Article Multidisciplinary Sciences

Detection of a SARS-CoV-2 variant of concern in South Africa

Houriiyah Tegally et al.

Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.

NATURE (2021)

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Letter Medicine, General & Internal

Neutralizing Activity of BNT162b2-Elicited Serum

Yang Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Cost-effectiveness of public health strategies for COVID-19 epidemic control in South Africa: a microsimulation modelling study

Krishna P. Reddy et al.

Summary: The study aimed to evaluate the clinical, economic outcomes, and cost-effectiveness of COVID-19 epidemic control strategies in KwaZulu-Natal province, South Africa. It identified cost-effective combinations of interventions, such as household contact tracing, isolation, mass symptom screening, and quarantining household contacts who test negative, that substantially reduce COVID-19 mortality.

LANCET GLOBAL HEALTH (2021)

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Article Multidisciplinary Sciences

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Sandile Cele et al.

Summary: The study compared the neutralization of non-VOC and 501Y.V2 VOC variants using plasma from COVID-19 patients in South Africa. It found that plasma from individuals infected during the first wave effectively neutralized the first-wave virus variant, while plasma from those infected in the second wave effectively neutralized the 501Y.V2 variant.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Modeling vaccination rollouts, SARS-CoV-2 variants and the requirement for non-pharmaceutical interventions in Italy

Giulia Giordano et al.

Summary: This study combines multiple models to predict the spread and consequences of COVID-19 cases, finding that non-pharmaceutical interventions have a greater impact on the epidemic evolution. Using a data-based model, different scenarios of vaccine rollouts and interventions are proposed to assess their impact on the pandemic.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

S. A. Madhi et al.

Summary: The ChAdOx1 nCoV-19 vaccine did not provide significant protection against mild-to-moderate Covid-19 caused by the B.1.351 variant, with an efficacy of 10.4%. The incidence of serious adverse events was balanced between the vaccine and placebo groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Medicine, General & Internal

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

Nicole Doria-Rose et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

V. Shinde et al.

Summary: The NVX-CoV2373 vaccine showed efficacy in preventing Covid-19, with higher vaccine efficacy observed among HIV-negative participants. Most infections were caused by the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Health Care Sciences & Services

Inpatient Care Costs of COVID-19 in South Africa's Public Healthcare System

Ijeoma Edoka et al.

Summary: "This study estimates the daily inpatient care costs of COVID-19 in South Africa through a micro-costing approach, finding that the average daily costs per patient increase with the level of care. The highest costs were for ICU admissions, while the lowest costs were for general ward-based care. The estimates are useful for informing budgeting and planning processes in South Africa and can be adapted for policy decisions in other contexts."

INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT (2021)

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Editorial Material Multidisciplinary Sciences

Count the cost of disability caused by COVID-19

Andrew Briggs et al.

NATURE (2021)

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Article Medicine, General & Internal

Accelerated vaccine rollout is imperative to mitigate highly transmissible COVID-19 variants

Pratha Sah et al.

Summary: The emergence of more contagious variants of SARS-CoV-2 raises concerns about increased cases and severe outcomes. Accelerating vaccine distribution can significantly reduce severe outcomes, with increasing daily vaccine doses from 1 to 3 million having the potential to prevent a large number of hospitalizations and deaths for variants with higher transmissibility.

ECLINICALMEDICINE (2021)

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Article Health Care Sciences & Services