4.4 Review

Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia

期刊

ONCOLOGY LETTERS
卷 23, 期 1, 页码 -

出版社

SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.13119

关键词

Let-7 microRNAs; leukemia; tumor therapy; regulatory factors

类别

向作者/读者索取更多资源

The Let-7 family of miRNAs plays a crucial role in various biological processes and is associated with tumor occurrence and prognosis. Let-7 is not only a potential diagnostic and prognostic marker for leukemia, but also a potential therapeutic target.
The lethal-7 (Let-7) family of microRNAs (miRNAs) controls the process of development and differentiation, but is also related to the occurrence of tumors and a poor prognosis of patients with tumors. Thus, a more comprehensive exploration of its functions will provide further insights into these processes, and may promote the diagnosis and treatment of tumors. Leukemia is a type of progressive malignant disease, and its pathogenesis involves a variety of epigenetic factors. Amongst the several related epigenetic factors, the Let-7 miRNAs are an important family of molecules that play a crucial role in maintaining a variety of critical biological processes, including development, differentiation and proliferation. In the present study, the role of Let-7 as a tumor suppressor gene and oncogene is reviewed, and the complex regulatory functions of several Let-7 family members in different subtypes of leukemia are described. The current body of knowledge thus far indicates that Let-7 is not only a potential diagnostic and prognostic marker of leukemia, but also a potential therapeutic target for the treatment of affected patients, with particular potential when targeted by adjuvant treatments alongside traditional treatment to improve their survival rate.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据