Treatments on the Horizon: Breast Cancer Patients with Central Nervous System Metastases

Purpose of Review The goal of this paper is to provide a review on the current emerging management strategies as described in the literature pertaining to breast cancer and central nervous system metastases. As systemic oncology treatments evolve, so are new approaches to the management of central nervous system metastases from breast cancer. Recent Findings In this review, we describe how novel treatment strategies have evolved from standard chemotherapy to more targeted approaches, innovative drug delivery methodologies, immunotherapeutics, and radiotherapeutic approaches. Summary We describe innovative treatment strategies on the horizon for breast cancer and central nervous metastases. Future therapeutics may be better able to penetrate through the blood-brain-barrier bypassing limitations from standard therapies. These pioneering strategies will hopefully improve patients' quality of life as well as survival.

Automated summary

This paper provides a review of emerging management strategies for breast cancer and central nervous system metastases. It discusses the evolution from standard chemotherapy to more targeted approaches, drug delivery methodologies, immunotherapeutics, and radiotherapeutic approaches. The future therapeutics may improve patients' quality of life and survival by bypassing the limitations of standard therapies.