相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Chloroform extract from Sophora Tonkinensis Gagnep. inhibit proliferation, migration, invasion and promote apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway
Shuo Wang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2021)
Targeting Wnt/β-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia
Cecilia Evangelisti et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2020)
The PI3K/mTOR dual inhibitor NVP-BEZ235 stimulates mutant p53 degradation to exert anti-tumor effects on triple-negative breast cancer cells
Jiajing Cai et al.
FEBS OPEN BIO (2020)
Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling
Rakshamani Tripathi et al.
NATURE COMMUNICATIONS (2020)
Targeting mTOR for cancer therapy
Hui Hua et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
Shigekazu Murakami et al.
DEVELOPMENTAL CELL (2019)
Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration
Chen Liu et al.
THERANOSTICS (2019)
YAP/TAZ Signaling and Resistance to Cancer Therapy
Chan D. K. Nguyen et al.
TRENDS IN CANCER (2019)
Hypoxia-inducible factor-1/interleukin-1 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment
Jingying Zhang et al.
HEPATOLOGY (2018)
Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-/Smad and PI3K/Akt/mTOR Signaling Pathways
Shangping Xing et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway
Yang Cheng et al.
MOLECULAR CANCER (2018)
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
Tyler Risom et al.
NATURE COMMUNICATIONS (2018)
Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway
Ho Jeong Lee et al.
NUTRIENTS (2018)
Vasculogenic mimicry formation in EBV-associated epithelial malignancies
Tong Xiang et al.
NATURE COMMUNICATIONS (2018)
PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer
Aziz Ur Rehman Aziz et al.
BIOMOLECULES (2018)
The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling
Huan-Tian Zhang et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
Shanshan Zhang et al.
JOURNAL OF HEPATOLOGY (2017)
Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence
Katherine R. Singleton et al.
CELL REPORTS (2017)
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Taru Muranen et al.
CANCER RESEARCH (2016)
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
Shaokun Shu et al.
NATURE (2016)
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
Zhipeng Meng et al.
NATURE COMMUNICATIONS (2015)
Strategic targeting of the PI3K-NFκB axis in cisplatin-resistant NSCLC
Susan Heavey et al.
CANCER BIOLOGY & THERAPY (2014)
Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC
Susan Heavey et al.
CANCER TREATMENT REVIEWS (2014)
Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
John Bridgewater et al.
JOURNAL OF HEPATOLOGY (2014)
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
Junwei Shi et al.
MOLECULAR CELL (2014)
\ Bromodomain and Extraterminal Domain Inhibitors (BETi) for Cancer Therapy: Chemical Modulation of Chromatin Structure
Jun Qi
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Targeting PI3K/Akt/mTOR signaling in cancer
Camillo Porta et al.
FRONTIERS IN ONCOLOGY (2014)
Development of PI3K inhibitors: lessons learned from early clinical trials
Jordi Rodon et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2013)
Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
Katrin Strassburger et al.
DEVELOPMENTAL BIOLOGY (2012)
Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila
Xin Ye et al.
DEVELOPMENTAL BIOLOGY (2012)
YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29
Karen Tumaneng et al.
NATURE CELL BIOLOGY (2012)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Clinical diagnosis and staging of cholangiocarcinoma
Boris Blechacz et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
Clinicopathological Prognostic Factors After Hepatectomy for Patients with Mass-Forming Type Intrahepatic Cholangiocarcinoma: Relevance of the Lymphatic Invasion Index
Ken Shirabe et al.
ANNALS OF SURGICAL ONCOLOGY (2010)
Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
Christian Werno et al.
CARCINOGENESIS (2010)
Selective inhibition of BET bromodomains
Panagis Filippakopoulos et al.
NATURE (2010)
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Sauveur-Michel Maira et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao et al.
GENES & DEVELOPMENT (2007)
Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?
M. N. Corradetti et al.
ONCOGENE (2006)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)