期刊
CELL DEATH & DISEASE
卷 12, 期 11, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41419-021-04303-5
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类别
资金
- National Natural Science Foundation of China [81772995, 81472266]
- Excellent Youth Foundation of Jiangsu Province, China [BK20140032]
- Jiangsu Province's Key Provincial Talents Program [ZDRCA 2016090]
The study demonstrates that Linc-ROR plays an oncogenic role in hepatocellular carcinoma through positive regulation of DEPDC1 expression, potentially serving as a target for anticancer therapies.
Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
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