4.7 Article

USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth

Yu-Ling Lee et al.

Summary: The study reveals that the Mediator complex directly interacts with E2A-PBX1 through the MED1 subunit, playing a critical role in regulating E2A-PBX1-dependent gene activation and leukemic cell growth. The findings highlight the functional importance of MED1 in gene-specific transcriptional activation and maintenance of E2A-PBX1-driven leukemia, suggesting potential therapeutic opportunities by targeting MED1 in E2A-PBX1(+) pre-B leukemia.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Si-Min Qi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Pharmacology & Pharmacy

USP7: Novel Drug Target in Cancer Therapy

Zhiru Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Biotechnology & Applied Microbiology

Deubiquitylating enzymes and drug discovery: emerging opportunities

Jeanine A. Harrigan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Biochemistry & Molecular Biology

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

Enis Afgan et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Medicine, Research & Experimental

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis

Dongxue Su et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Pharmacology & Pharmacy

USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth

Tao An et al.

BIOCHEMICAL PHARMACOLOGY (2017)

Article Genetics & Heredity

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Liacine Bouaoun et al.

HUMAN MUTATION (2016)

Article Biochemistry & Molecular Biology

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

Omid Tavana et al.

NATURE MEDICINE (2016)

Article Cell Biology

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression

Kazunobu Isogaya et al.

CELL RESEARCH (2014)

Article Multidisciplinary Sciences

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Maria Stella Ritorto et al.

NATURE COMMUNICATIONS (2014)

Review Cell Biology

The regulation of TGF-β/SMAD signaling by protein deubiquitination

Juan Zhang et al.

PROTEIN & CELL (2014)

Article Biochemistry & Molecular Biology

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte et al.

Article Multidisciplinary Sciences

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali et al.

SCIENCE (2013)

Article Chemistry, Medicinal

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

Joseph Weinstock et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

The Multifaceted Roles of USP7: New Therapeutic Opportunities

Benjamin Nicholson et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Biochemistry & Molecular Biology

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

Mikael Altun et al.

CHEMISTRY & BIOLOGY (2011)

Article Multidisciplinary Sciences

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Biochemistry & Molecular Biology

The emerging complexity of protein ubiquitination

David Komander

BIOCHEMICAL SOCIETY TRANSACTIONS (2009)

Article Biochemistry & Molecular Biology

4E-BP1 is a target of Smad4 essential for TGFβ-mediated inhibition of cell proliferation

Rania Azar et al.

EMBO JOURNAL (2009)

Article Oncology

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

Frederic Colland et al.

MOLECULAR CANCER THERAPEUTICS (2009)

Article Multidisciplinary Sciences

ChIP-seq accurately predicts tissue-specific activity of enhancers

Axel Visel et al.

NATURE (2009)

Review Multidisciplinary Sciences

Targeting the ubiquitin system in cancer therapy

Daniela Hoeller et al.

NATURE (2009)

Review Multidisciplinary Sciences

Origin and function of ubiquitin-like proteins

Mark Hochstrasser

NATURE (2009)

Review Cell Biology

Breaking the chains: structure and function of the deubiquitinases

David Komander et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Ubiquitination regulates PTEN nuclear import and tumor suppression

Lloyd C. Trotman et al.

Article Cell Biology

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

Armando van der Horst et al.

NATURE CELL BIOLOGY (2006)

Review Biochemistry & Molecular Biology

A genomic and functional inventory of deubiquitinating enzymes

SMB Nijman et al.

Article Biochemistry & Molecular Biology

A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

Article Developmental Biology

TGF-β is required for programmed cell death in interdigital webs of the developing mouse limb

N Dünker et al.

MECHANISMS OF DEVELOPMENT (2002)

Article Biochemistry & Molecular Biology

Balancing the activation state of the endothelium via two distinct TGF-β type I receptors

MJ Goumans et al.

EMBO JOURNAL (2002)