期刊
HPB
卷 24, 期 5, 页码 681-690出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.hpb.2021.10.017
关键词
-
资金
- National Natural Science Foundation of China [81772950, 82073249, 81773160, 81874205]
- Hubei Natural Science Foundation [WJ2017Z010, 2019CR203]
- Tongji Hospital Clinical Research Flagship Program [WJ2017Z010]
- Hubei Natural Science Foundation [2019CR203, 2017CFB467]
- National Key Research and Development Program of China [WJ2017Z010]
- Tongji Hospital Science Fund for Distinguished Young Scholars
- [2019TFC1315905]
In this study, we validated the value of AJCC 8 and other coexisting staging systems for well differentiated pNETs. The results showed that AJCC 8 had a more reasonable proportional distribution and the risk of death was better correlated with disease stage.
Background: The American Joint Committee on Cancer (AJCC) made improvements for staging pancreatic neuroendocrine tumors (pNETs) in its 8th Edition; however, multicenter studies were not included. Methods: We collected multicenter datasets (n = 1,086, between 2004 and 2018) to validate the value of AJCC 8 and other coexisting staging systems through univariate and multivariate analysis for well differentiated (G1/G2) pNETs. Results: Compared to other coexisting staging systems, AJCC 7 only included 12 (1.1%) patients with stage III tumors. Patients with European Neuroendocrine Tumor Society (ENETS) stage IIB disease had a higher risk of death than patients with stage IIIA (hazard ratio [HR]: 4.376 vs. 4.322). For the modified ENETS staging system, patients with stage IIB disease had a higher risk of death than patients with stage III (HR: 6.078 vs. 5.341). According to AJCC 8, the proportions of patients with stage I, II, III, and IV were 25.7%, 40.3%, 23.6%, and 10.4%, respectively. As the stage advanced, the median survival time decreased (NA, 144.7, 100.8, 72.0 months, respectively), and the risk of death increased (HR: II = 3.145, III = 5.925, and IV = 8.762). Conclusion: These findings suggest that AJCC 8 had a more reasonable proportional distribution and the risk of death was better correlated with disease stage.
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