期刊
JOURNAL OF FUNCTIONAL FOODS
卷 88, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104896
关键词
Recombinant Subtilisin QK-2; Thrombosis; Fibrinolysis; Thrombolysis; D-dimer; Fibrin; fibrinogen degradation products (FDPs)
资金
- Health Commission of Hubei Province Scientific Research Project [WJ2019Q040]
- Fundamental Research Funds for the Central Universities [2042018kf0034]
Thrombosis is a major cause of death worldwide and the currently available drugs for treatment have limitations. Subtilisin QK, as a potential oral thrombolytic agent, has a high fibrinolytic activity and can be absorbed and exert thrombolytic effects in the body.
Thrombosis is a severe health care issue and one of the leading causes of death globally. Since presently used drugs have a number of limitations, safe and effective thrombolytic agents are still needed. Subtilisin QK, widely used as a component of functional food, presents high direct cross-linked fibrin degradation, without activation of plasminogen. It could be absorbed throughout intestine and infiltrate into all organs with fibrinolytic activity against the pancreatic enzyme and acidic pH mimicking the stomach in a time-dependent manner. Oral intake of rSubtilisin QK also elevated levels of fibrin/fibrinogen degradation products, D-dimer, and tissue plasminogen activator (t-PA) in plasma, and alleviated ear-and tail-thrombosis in kappa-carrageenan-induced model. Furthermore, the levels of t-PA were increased in cultured HUVECs stimulated with rSubtilisin QK, while plasminogen activator inhibitor-1 showed the opposite trend simultaneously, suggesting the activation of plasminogen. In conclusion, rSubtilisin QK exerted thrombolytic effects in vivo and may be a potential oral thrombolytic agent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据