期刊
JOURNAL OF FUNCTIONAL FOODS
卷 85, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104614
关键词
Quercetin; Brown adipose tissue; Inflammation; Oxidative stress; microRNA
资金
- United States Department of Agri-culture [NC.X-310-5-18-170-1]
Quercetin improves obesity-induced inflammation in BAT by suppressing the NF kappa B pathway through activation of SIRT1.
Inflammation in brown adipose tissue (BAT) causes BAT to lose its ability to regulate energy metabolism, which exacerbates obesity development. This study investigated the anti-inflammatory and antioxidant effects of quercetin on BAT in high-fat diet (HFD)-induced obese mice. Quercetin reduced proinflammatory and macrophage genes and increased antioxidant genes in the BAT of HFD-fed mice and in TNF alpha-induced brown adipocytes. In addition to increasing silent mating type information regulation 2 homolog 1 (SIRT1) levels, quercetin suppressed nuclear translocation and increased deacetylation of the nuclear factor kappa B (NF kappa B) subunit p65. The effects of quercetin on SIRT1 and NF kappa B p65 deacetylation disappeared in SIRT1-knockdown brown adipocytes. MicroRNAs that negatively regulate SIRT1 were downregulated in the BAT of HFDQ-fed mice. Taken together, these results suggest that quercetin improves obesity-induced inflammation in BAT by suppressing the NF kappa B pathway through activation of SIRT1.
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