期刊
JOURNAL OF FUNCTIONAL FOODS
卷 85, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104608
关键词
Polyphenols; Phytochemicals; Diabetic retinopathy; Vascular endothelial growth factor; Antioxidant; Anti-inflammatory
Diabetes retinopathy (DR) is a common microvascular complication of diabetes, leading to blindness, and the current available therapies lack long-term efficacy and safety assessment. Therefore, there is a need to find more reliable and effective treatments, with plant-derived polyphenols showing promise as an alternative option.
Diabetes retinopathy (DR) is the leading cause of blindness and is considered as the most ordinary microvascular complication of diabetes mellitus (DM). The current available therapies can only be effective in the progressive stages of DR and there are various clinical studies which depicts the inconclusive outcomes of these available therapies after assessing the long-term efficacy and safety of such treatments. Moreover, there is an indispensable need of a more reliable as well as potent treatment which can be considered as more efficacious treatment for the management of DR. The treatment of DR can be possible at the early stages with polyphenols which are plant derived chemical agents and can be act as an alternative to other treatments and can optimistically prevent the further evolution of disease. The present review emphasizes the role of polyphenols on cellular and molecular mechanisms altered by DR in preclinical and clinical studies.
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