期刊
JOURNAL OF FUNCTIONAL FOODS
卷 86, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104730
关键词
Gut microbiota; Ginsenoside Rb1; Immune enhancement; Metagenomic analysis; Lactobacillus; Akkermansia
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2019R1I1A1A01063354]
The study found that the immune enhancement effects of ginsenoside Rb1 (G-Rb1) were more significant when a high proportion of Lactobacillus already existed in the intestines of mice. Additionally, the intake of G-Rb1 increased the abundance of the genus Akkermansia in the intestine, which is beneficial for the immune system.
This study aimed to identify correlations between the immune enhancement effects of ginsenoside Rb1 (G-Rb1) and the composition of the gut microbiota in mice. Feces samples collected from mice with high (HI) and low (LI) immune enhancement before and after the feeding of a diet supplemented with G-Rb1 were assessed via metagenomic analysis. Before feeding the G-Rb1 diet, the proportion of the genus Lactobacillus was higher in the HI group than that in the LI group. After feeding the G-Rb1 diet, the abundance of the genus Akkermansia increased particularly in the HI group. Taken together, our findings indicate that it can enhance the effect of G-Rb1 when a high proportion of Lactobacillus already remains in the intestine and that G-Rb1 intake increases the proportion of Akkermansia in the intestine, which has various beneficial effects, especially on the immune system.
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