期刊
BMC NEPHROLOGY
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12882-021-02569-7
关键词
Hemodialysis; Chronic kidney disease; Potassium; Hyperkalemia; Sodium zirconium cyclosilicate
资金
- AstraZeneca
These analyses expand our knowledge of the spectrum of potassium responses with SZC in hyperkalemic hemodialysis patients, and suggest that SZC has better control over potassium gradient compared to placebo.
Background: Sodium zirconium cyclosilicate (SZC) is an effective and well-tolerated treatment for hyperkalemia in maintenance hemodialysis patients. In post-hoc analyses of the phase 3b DIALIZE study, we examined the spectrum of potassium responses to SZC. Methods: Post-hoc analyses with SZC and placebo included: the number of long interdialytic interval (LIDI) visits during the 4-week evaluation period where patients attained pre-dialysis serum potassium (sK(+)) concentrations of 4.0-5.0 and 4.0-5.5 mmol/L; potassium gradient (the difference between pre-dialysis sK(+) and dialysate potassium) at days 36, 43, 50, and 57, and change from baseline to the end of treatment (EOT) using categories of potassium gradient (1 to < 2, 2 to < 3, 3 to < 4, and >= 4 mmol/L). Results: A greater proportion of patients achieved the ranges of pre-dialysis sK(+) concentration with SZC versus placebo for >= 1, >= 2, >= 3, and 4 LIDI visits over 4 weeks; 23.7 and 48.5% of patients in the SZC group achieved pre-dialysis sK(+) concentrations of 4.0-5.0 and 4.0-5.5 mmol/L, respectively, at all 4 LIDI visits. Baseline mean potassium gradient was similar with SZC and placebo. At day 57, mean (standard deviation) potassium gradient was 2.78 (0.08) mmol/L with SZC and 3.52 (0.08) mmol/L with placebo; mean difference (95% confidence interval) was - 0.74 mmol/L (- 0.97 to - 0.52). A greater reduction in potassium gradient category from baseline towards lower-risk categories at EOT was observed with SZC versus placebo. Conclusions: These analyses expand our knowledge of the spectrum of potassium responses with SZC in hyperkalemic hemodialysis patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据