Enantioselective difunctionalization of alkenes by a palladium-catalyzed Heck/borylation sequence

A palladium catalyzed enantioselective Heck/borylation reaction of alkene-tethered aryl iodides was realized, delivering a variety of 2,3-dihydrobenzofuranyl boronic esters in high yield with excellent enantioselectivity. Asymmetric synthesis of chromane boronic ester, indane boronic ester and indoline boronic ester was also accomplished. The protocol offers an efficient access to the corresponding chiral benzocyclic boronic esters, which are notably important chemical motifs in synthetic transformations.

Automated summary

A palladium catalyzed enantioselective Heck/borylation reaction of alkene-tethered aryl iodides was developed, providing a range of 2,3-dihydrobenzofuranyl boronic esters with high yield and excellent enantioselectivity. Asymmetric synthesis of chromane boronic ester, indane boronic ester and indoline boronic ester was also achieved.