期刊
CHEMICAL SCIENCE
卷 13, 期 4, 页码 1003-1008出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc06577g
关键词
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资金
- NSFC [21971101, 21801126, 22171127]
- Thousand Talents Program for Young Scholars, Guangdong Basic and Applied Basic Research Foundation [2019A1515011976]
- Department of Education of Guangdong Province [2021KTSCX06]
- Stable Support Plan Program of Shenzhen Natural Science Fund [20200925152608001]
- Pearl River Talent Recruitment Program [2019QN01Y261]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
- SUSTech [CCDC 2110292, 2107074, 2110458dagger]
A transition-metal-free protocol for selective allylic C-H nitrogenation, oxygenation, and carbonation of alkenes has been developed, providing multialkyl substituted allylic amines, ammonium salts, sulfonyl amides, esters, and ethers in good yields. The reaction shows excellent functional group tolerance and can be applied to the late-stage allylation of natural products, drug molecules, and peptides with high chemoselectivity.
Selective functionalization of allylic C-H bonds into other chemical bonds is among the most straightforward and attractive, yet challenging transformations. Herein, a transition-metal-free protocol for direct allylic C-H nitrogenation, oxygenation, and carbonation of alkenes by thianthrenation was developed. This operationally simple protocol allows for the unified allylic C-H amination, esterification, etherification, and arylation of vinyl thianthrenium salts. Notably, the reaction furnishes multialkyl substituted allylic amines, ammonium salts, sulfonyl amides, esters, and ethers in good yields. The reaction proceeds under mild conditions with excellent functional group tolerance and could be applied to late-stage allylation of natural products, drug molecules and peptides with excellent chemoselectivity.
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