☆ 4.6 Article

Macrophages and Monocytes: Trojan Horses in COVID-19

VIRUSES-BASEL (2021)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis

Asma Boumaza et al.

Summary: The study found that monocytes and macrophages from COVID-19 patients can be infected by SARS-CoV-2, leading to secretion of immunoregulatory cytokines and induction of a specific transcriptional program in macrophages. Single-cell analysis in COVID-19 patients revealed lower monocyte counts affecting all subsets, decreased expression of HLA-DR, and increased expression of CD163, regardless of disease severity.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy

Claudia Alteri et al.

Summary: The Lombardy region of Italy was heavily affected early in the SARS-CoV-2 pandemic. Using whole genome sequencing, researchers found multiple virus introductions into the region with transmission occurring before the first case was detected.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

Raoul De Gasparo et al.

Summary: The bispecific IgG1-like molecule CoV-X2 can simultaneously bind two independent sites on the RBD, prevent spike binding to ACE2, neutralize SARS-CoV-2 and its variants, and protect mice from disease in a mouse model of SARS-CoV-2 infection. This demonstrates the feasibility and efficacy of targeting non-overlapping RBD epitopes with IgG-like bispecific antibodies.

NATURE (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 Induces Lymphocytopenia by Promoting Inflammation and Decimates Secondary Lymphoid Organs

Qun Xiang et al.

Summary: The study retrospectively reviewed clinical and immunological data from fatal COVID-19 cases and found severe lymphocytopenia with high levels of inflammatory cytokines. Post-mortem examinations of additional cases showed severe tissue damage and lymphocyte apoptosis in spleens and lymph nodes, where SARS-CoV-2 viral RNA accumulates, leading to lymphocytopenia. Overall, the results suggest that SARS-CoV-2 induces lymphocytopenia by promoting systemic inflammation and direct damage to human spleen and lymph nodes.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells

Jana Koch et al.

Summary: SARS-CoV-2 infects cells through two mutually exclusive pathways depending on the presence of TMPRSS2 protease. In the presence of TMPRSS2, the virus swiftly enters through the plasma membrane in a pH-independent manner; while in the absence of TMPRSS2, the virus is endocytosed and enters the cytosol post-infection.

EMBO JOURNAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

Florian A. Lempp et al.

Summary: The study reveals that C-type lectin receptors and other factors can serve as attachment receptors for SARS-CoV-2 infection, enhancing ACE2-mediated infection and modulating the neutralizing activity of antibodies.

NATURE (2021)

添加到收藏夹

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

添加到收藏夹

Article Dentistry, Oral Surgery & Medicine

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

Hao Xu et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Article Infectious Diseases

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Elena Percivalle et al.

EUROSURVEILLANCE (2020)

添加到收藏夹

Review Cell Biology

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

Tahmineh Mokhtari et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

添加到收藏夹

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

添加到收藏夹

Article Virology

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

Kazuya Shirato et al.

VIROLOGY (2018)

添加到收藏夹

Article Virology

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

Kazuya Shirato et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Review Virology

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

Jie Zhou et al.

VIROLOGY JOURNAL (2015)

添加到收藏夹

Article Hematology

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

Noura Ismail et al.

BLOOD (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients

S Keidar et al.

CIRCULATION RESEARCH (2005)

添加到收藏夹

Article Obstetrics & Gynecology

Use of a novel washing method combining multiple density gradients and trypsin for removing human immunodeficiency virus-1 hepatitis C from semen

NM Loskutoff et al.

FERTILITY AND STERILITY (2005)

添加到收藏夹

Article Virology

SARS-coronavirus replication in human peripheral monocytes/macrophages

M Yilla et al.

VIRUS RESEARCH (2005)

添加到收藏夹

Article Immunology

In vitro detection of apoptosis in monocytes/macrophages infected with human coronavirus

AR Collins

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.