期刊
VIRUSES-BASEL
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/v13112145
关键词
African swine fever; dual infection; phylogenetic analysis; whole genome sequence; Sardinia
类别
资金
- Italian Ministry of Health [IZSUM PSRC 1/2018]
The research identifies two cases of intragenotype dual African swine fever virus infections in Sardinia, indicating that dual infections or similar virus strains may be more common than previously thought, especially in ASF endemic areas.
African swine fever virus (ASFV) is one of the pathogens of highest concern worldwide. Despite different virus lineages co-circulating in several areas, dual infections in the same animal have been rarely observed, suggesting that ASF superinfections are infrequent events. Here we present the first genome-wide detection and analysis of two intragenotype dual ASFV infections. The dual infections have been detected in a hunted wild boar and in a pig carcass, both infected by ASFV genotype I in Sardinia in 1984 and 2018, respectively. We characterize the genetic differences between the two sequences, their intra-host frequency, and their phylogenetic relationship among fully sequenced ASFV strains from Sardinia. Both dual infections involve pairs of closely related but different viruses that were circulating in Sardinia in the same period. The results imply that dual ASFV infections or similar ASFV strains are more common than expected, especially in ASF endemic areas, albeit difficult to detect.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据