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Article
Multidisciplinary Sciences
Peter J. Halfmann et al.
Summary: The recent study by the SAVE/NIAID network shows that the B.1.1.529 Omicron variant causes milder lung disease in rodents, which is consistent with preliminary human clinical data.
Review
Dentistry, Oral Surgery & Medicine
Momen A. Atieh et al.
Summary: Saliva testing has shown high sensitivity and specificity in detecting SARS-CoV-2. Further large-scale studies are needed for validation and to determine safe sample collection methods prior to widespread use. The use of saliva allows for easy self-collection of specimens and can be conducted in outpatient and community clinics.
Review
Microbiology
Olivier Vandenberg et al.
Summary: In this review, Vandenberg et al. explore the crucial role of diagnostic tests during the early phase of the COVID-19 pandemic, addressing technical and implementation issues encountered and suggesting future directions for improved diagnostics in potential future outbreaks.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Infectious Diseases
Nancy Matic et al.
Summary: Amid the global shortage of flocked nasopharyngeal swabs and viral transport media, alternative diagnostic specimens for SARS-CoV-2 detection, such as saliva samples, are being sought. Saliva samples showed good agreement with nasopharyngeal swabs in detecting SARS-CoV-2, with some barriers observed in collecting saliva from long-term care residents and outbreak settings. Additionally, the study indicated that SARS-CoV-2 RNA remains stable in human saliva at room temperature for up to 48 hours after collection.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Antonio Piralla et al.
Summary: Real-time reverse transcription PCR is currently the most sensitive method to detect SARS-CoV-2. In this study, virus isolation was attempted in nasal swabs with low viral load from recovered patients, resulting in a 2.3% culture positivity rate with cytopathic effect detected in nine samples. This study helps to understand true virus replication and residual viral RNA detection in recovered patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Alvin Kuo Jing Teo et al.
Summary: The study found saliva to be a sensitive sample for COVID-19 diagnosis, with a higher positivity rate compared to nasopharyngeal and self-administered nasal swabs. Cycle threshold values were lower across all sample types during the early stage of infection.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Bruno Fernandes Matuck et al.
Summary: The study shows that salivary glands serve as a reservoir for SARS-CoV-2, providing important insights for the diagnostic method of COVID-19, and highlighting the role of saliva in viral transmission.
JOURNAL OF PATHOLOGY
(2021)
Review
Genetics & Heredity
Tim R. Mercer et al.
Summary: The assembly and publication of the SARS-CoV-2 genome in January 2020 allowed for immediate development of tests and led to the largest global testing programme in history. Despite efforts to control the spread, widespread community transmission of the virus has become entrenched in many countries, necessitating population-scale testing to identify and isolate infected individuals. Testing plays a crucial role in the response to the COVID-19 pandemic and is likely to continue to be vital in public health.
NATURE REVIEWS GENETICS
(2021)
Editorial Material
Critical Care Medicine
Steph H. Tan et al.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Infectious Diseases
Lucas Zhou et al.
Summary: During the global vaccination rollout, it is crucial to thoroughly understand the modes of transmission of the virus to prevent further spread; SARS-CoV-2 is primarily transmitted among humans through respiratory droplets, with environmental factors also playing a role; Wearing masks, maintaining social distancing, and washing hands are effective public health strategies in reducing the risk of exposure and transmission.
BMC INFECTIOUS DISEASES
(2021)
Review
Medicine, Research & Experimental
Ibrahim Warsi et al.
Summary: Saliva, as a versatile specimen option, offers significant advantages in mass screening strategies for detecting SARS-COV-2. Through analysis of data from ten published clinical studies, a high degree of diagnostic sensitivity (87%) and specificity (98%) for SARS-COV-2 detection in saliva was established.
Article
Immunology
Isabel M. Ott et al.
Summary: Although saliva collection devices designed to stabilize SARS-CoV-2 RNA are expensive, the virus RNA in non-supplemented saliva remains stable for extended periods even at elevated temperatures. Simple plastic tubes for saliva collection can facilitate large-scale testing and continuous surveillance.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Priyanka Kapoor et al.
Summary: Saliva as an alternate diagnostic sample for SARS-CoV-2 infection offers advantages such as simple sample collection method, point-of-care testing for initial screening in community or hospital settings, and reducing patient discomfort. However, there is heterogeneity and gaps in methodology in the current literature, highlighting the need for more robust study design to generate higher levels of evidence.
Article
Immunology
Kelvin Kai-Wang To et al.
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
Chaolin Huang et al.
Letter
Infectious Diseases
Yang Pan et al.
LANCET INFECTIOUS DISEASES
(2020)
Editorial Material
Dentistry, Oral Surgery & Medicine
L. Pascolo et al.
JOURNAL OF DENTAL RESEARCH
(2020)
Editorial Material
Medicine, General & Internal
Francisco M. Marty et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Letter
Infectious Diseases
Jialou Zhu et al.
JOURNAL OF INFECTION
(2020)
Article
Medicine, General & Internal
Jing Lu et al.
