期刊
VIRUSES-BASEL
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v13102101
关键词
HAV; HIV; microbiome
类别
资金
- Japan Agency for Medical Research and Development (AMED) [18kk0205011, 20jk0210022, 20fk0108122]
- AMED-JICA (the Science and Technology Research Partnership for Sustainable Development: SATREPS) [20jm0110012h0006]
- Ministry of Health
- Labour, and Welfare of Japan [19HC1001, 21HC2001, 21HB2005]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP18H05280]
This study comprehensively observed the amount of virus excreted into the intestinal tract, changes in the intestinal microbiome, and the level of inflammation during the healing process in patients with HAV infection. The results showed that the virus could be shed for more than 150 days post-infection, pro-inflammatory cytokines were elicited immediately after infection and dysbiosis of the intestinal microbiome occurred and continued for a long time after healing.
Hepatitis A virus (HAV) causes transient acute infection, and little is known of viral shedding via the duodenum and into the intestinal environment, including the gut microbiome, from the period of infection until after the recovery of symptoms. Therefore, in this study, we aimed to comprehensively observe the amount of virus excreted into the intestinal tract, the changes in the intestinal microbiome, and the level of inflammation during the healing process. We used blood and stool specimens from patients with human immunodeficiency virus who were infected with HAV during the HAV outbreak in Japan in 2018. Moreover, we observed changes in fecal HAV RNA and quantified the plasma cytokine level and gut microbiome by 16S rRNA analysis from clinical onset to at least 6 months after healing. HAV was detected from clinical onset up to a period of more than 150 days. Immediately after infection, many pro-inflammatory cytokines were elicited, and some cytokines showed different behaviors. The intestinal microbiome changed significantly after infection (dysbiosis), and the dysbiosis continued for a long time after healing. These observations suggest that the immunocompromised state is associated with prolonged viral shedding into the intestinal tract and delayed recovery of the intestinal environment.
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