期刊
VIRUSES-BASEL
卷 14, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v14010051
关键词
IAV; miRNA; lncRNA; circRNA; interferon; antiviral innate immune response
类别
资金
- Fundamental Research Funds for the Central Universities [31920210033]
- Science and technology project of Gansu Province [20JR10RA121, 18JR2JA004]
- National Natural Science Foundation of China [32160164]
Host non-coding RNAs play an important regulatory role in the replication of influenza A virus (IAV). They directly target key proteins of IAV and indirectly participate in the regulation of multiple signal pathways. The findings provide a comprehensive understanding of the function and mechanism of host non-coding RNAs in the cellular anti-virus response, and offer clues to the mechanism of cell-virus interactions and the discovery of antiviral drug targets.
Outbreaks of influenza, caused by the influenza A virus (IAV), occur almost every year in various regions worldwide, seriously endangering human health. Studies have shown that host non-coding RNA is an important regulator of host-virus interactions in the process of IAV infection. In this paper, we comprehensively analyzed the research progress on host non-coding RNAs with regard to the regulation of IAV replication. According to the regulation mode of host non-coding RNAs, the signal pathways involved, and the specific target genes, we found that a large number of host non-coding RNAs directly targeted the PB1 and PB2 proteins of IAV. Nonstructural protein 1 and other key genes regulate the replication of IAV and indirectly participate in the regulation of the retinoic acid-induced gene I-like receptor signaling pathway, toll-like receptor signaling pathway, Janus kinase signal transducer and activator of transcription signaling pathway, and other major intracellular viral response signaling pathways to regulate the replication of IAV. Based on the above findings, we mapped the regulatory network of host non-coding RNAs in the innate immune response to the influenza virus. These findings will provide a more comprehensive understanding of the function and mechanism of host non-coding RNAs in the cellular anti-virus response as well as clues to the mechanism of cell-virus interactions and the discovery of antiviral drug targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据