Crosstalk between Hepatitis B Virus and the 3D Genome Structure

Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.

Automated summary

Viruses that transcribe their DNA within the nucleus have to adapt to cellular mechanisms governing transcriptional regulation. This review provides an updated overview of how hepatitis B virus interacts with the cellular 3D genome and its impact on viral and cellular gene expression. The strategies employed by other DNA viruses to manipulate cellular genome spatial organization are also briefly discussed.