4.6 Article

A Sex-Stratified Analysis of Monocyte Phenotypes Associated with HIV Infection in Uganda

期刊

VIRUSES-BASEL
卷 13, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/v13112135

关键词

monocytes; inflammation; activation; HIV; women; sex

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资金

  1. National Center for Advancing Translational Sciences at the National Institutes of Health [KL2 TR001426]
  2. National Heart, Lung, and Blood Institute at the National Institutes of Health [K23 HL123341]

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Women with HIV may experience higher rates of non-AIDS comorbidities compared to men with HIV, and there are sex-related differences in monocyte phenotypes. However, our study found that HIV affects monocyte subsets similarly in both men and women, without significant interactions between sex and HIV status.
Women with HIV may experience higher rates of non-AIDS comorbidities compared to men with HIV, but the underlying mechanisms are not well understood. We investigated sex-related differences in the effects of HIV on monocyte phenotypes within the Ugandan Study of HIV effects on the Myocardium and Atherosclerosis (mUTIMA). Of 133 participants who provided blood for flow cytometry assays, 86 (65%) were women and 91 (68%) were persons living with HIV (PLWH) on antiretroviral therapy. The median age was 57 (interquartile range, 52-63) years. PLWH exhibited a lower proportion of circulating CD14(+)CD16 classical monocytes (66.3% vs. 75.1%; p < 0.001), and higher proportion of CD14(+)CD16(+) inflammatory monocytes (17% vs. 11.7%; p = 0.005) compared to HIV-uninfected participants. PLWH had an increased expression of the chemokine receptor CX3CR1 in total monocytes (CX3CR1(+) monocytes, 24.5% vs. 4.7%; p < 0.001) and monocyte subsets. These findings were generally similar when analyzed by sex, with no significant interactions between sex and HIV status in adjusted models. Our data show that the inflammatory monocyte subset is expanded and monocyte CX3CR1 chemokine receptor expression is enhanced among PLWH, regardless of sex. Whether these parameters differentially affect risk for non-AIDS comorbidities and clinical outcomes in women with HIV requires additional investigation.

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